Guard Column cartridge, Bidentate C8, replacement, 2.0 mm ID x 10 mm long cartridge packed with 4 um, 100 A phase. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40008‑PG3 Cogent Bidentate C8 Guard Column Cartridge is a single replacement cartridge designed to protect analytical HPLC columns from particulates, strongly retained compounds, and sample contamination, while maintaining chromatographic performance.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 4 µm, 100 Å TYPE‑C™ silica hydride Bidentate C8 phase
Constructed in stainless steel housing with SS frits
The cartridge is supplied individually in a protective Delrin™ case, preventing contamination, drying, or physical damage prior to use.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm Analytical Columns
This cartridge is specifically optimized for:
2.1 mm ID analytical HPLC columns
LC‑MS and low‑flow analytical systems
High‑sensitivity workflows
Proper matching ensures:
Minimal peak dispersion
Stable retention and selectivity
Consistent analytical reproducibility
Why Use a Single Guard Cartridge
A single‑cartridge configuration is ideal when:
Testing different guard phases across methods
Replacing cartridges individually as needed
Running multiple methods requiring different selectivities
Minimizing upfront cost while maintaining column protection
It provides flexibility compared to multi‑pack options while still delivering full protection.
Why Use Guard Column Protection
Analytical columns are exposed to:
Particulates from samples or mobile phases
Strongly retained analytes
Matrix buildup from complex samples
Irreversible adsorption
The 40008‑PG3 cartridge acts as a sacrificial protection layer, helping to:
Extend analytical column lifetime
Maintain performance and efficiency
Reduce system downtime
Lower overall operating costs
Bidentate C8 Guard Phase Advantages
Using the same stationary phase as your analytical column ensures:
Matched selectivity and retention behavior
No unexpected chromatographic shifts
Seamless analyte transfer
Compared to C18 phases, Bidentate C8:
Reduces excessive hydrophobic retention
Improves recovery of amine-containing compounds
Provides alternative selectivity for complex samples
Supports faster equilibration
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Reduced silanol activity
Improved peak shape for basic compounds
Lower secondary interactions
Faster Equilibration
Reduced cycle times
Increased throughput
Durability
Resistant to hydrolysis
Long cartridge life
Stable in demanding analytical conditions
Typical Applications
LC‑MS analytical methods
Pharmaceutical and metabolite analysis
Complex sample matrices
Amine‑containing compounds
Method development requiring phase flexibility